Acne is a chronic inflammatory skin disease in the pilosebaceous unit. It is mainly found in adolescents and has a great psychological and social impact on adolescents. However, adolescence tends to naturally relieve or heal. The clinical manifestations are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules that often occur on the face.
The occurrence of acne is mainly related to factors such as excessive sebum secretion, hair follicle sebaceous gland conduit blockage, bacterial infection and inflammatory reaction and other factors. After entering puberty, the level of androgens, especially testosterone, in the human body rapidly rises, promoting sebaceous gland development and producing large amounts of sebum. At the same time, abnormal keratinization of the hair follicle sebaceous ducts leads to blockage of the catheter, and the sebum is discharged to form a horny plug, ie, acne. A variety of micro-organisms in the hair follicles, in particular Propionibacterium acnes, proliferate. The lipase produced by Propionibacterium acnes breaks down the sebum to produce free fatty acids, chematizes inflammatory cells and mediators, and ultimately induces and aggravates the inflammatory response.
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